According to ESPN College Football Insider Brett McMurphy, Alabama will open their 2018 season against Louisville in the Orlando Kickoff on September 1.
Alabama & Louisville will open 2018 season (Sept. 1, 2018) in Orlando sources told @ESPN
— Brett McMurphy (@McMurphyESPN) July 31, 2015
The two teams have only faced each other three times, with Alabama holding a 2-1 series lead. The Cardinals only victory was in the 1991 Fiesta Bowl, winning 34-7.